IN SILICO RESEARCH SOFTWARE
"Solving these equations using computer software allows us to run detailed simulations to mimic the heart's electrical activity."Ĭomputational models of the heart linking cellular electrophysiology to whole-organ behavior are emerging as promising platforms for in-silico evaluation of novel diagnostic and therapeutic strategies. Trayanova, a co-author and professor of biomedical engineering and medicine at Johns Hopkins University. This complex biophysical system "can be represented using a set of mathematical equations," said Natalia A.
These models include most of the biophysical complexity of an individual patient's cardiac pathology. Whole-heart computational models are multiscale, which means they factor in both cellular- and organ-level properties. The heart's electrical properties can be modeled via fundamental biophysical principles determined through basic science experiments.
In Biophysics Reviews, from AIP Publishing, the researchers describe the progress using various computational approaches to address the mechanisms of cardiac dysfunction and issues related to the clinical application of computation-driven diagnostic and therapeutic approaches for cardiac disease and arrhythmias.
To pursue a better mechanistic understanding of ventricular arrhythmias, Johns Hopkins University researchers are turning to whole-heart computational models. Ventricular arrhythmias, which are abnormal heartbeats, are one of the leading causes of mortality worldwide.
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